Maladaptive Repair The ultimate goal of regenerative medicine is the restoration of native parenchymal function. However, a critical risk exists in the administration of poorly characterized multipotent cells: the induction of maladaptive repair, wherein inflamed, functional tissue is permanently converted into non-functional fibrotic scar tissue. Aberrant Differentiation and the FOP Paradigm An extreme biological precedent…

A Paradigm Shift in Targeted Bio-Calibration Abstract / Summary Traditional pharmacological immunosuppression relies on the systemic inactivation or depletion of immune cascades to halt tissue damage. While effective, this approach imposes a global compromise on host immunity, disrupts physiological remodeling, and risks severe off-target toxicity. In contrast, mesenchymal stromal cell (MSC)-mediated immunomodulation operates as an…